Which medication should be avoided with selegiline due to serious interaction risk?

Which medication should be avoided with selegiline due to serious interaction risk?

• A. Meperidine
• B. Acetaminophen
• C. Ibuprofen
• D. Loratadine

Answer: (A)

Combining selegiline with drugs that affect serotonin or other monoamines can trigger life‑threatening interactions. Meperidine has serotonergic properties, and when used with MAO inhibitors like selegiline, it can precipitate serotonin syndrome and dangerous blood pressure changes. This risk makes it essential to avoid this pairing. Acetaminophen and ibuprofen don’t carry that same serotonergic interaction with MAOIs, and loratadine is an antihistamine with no strong MAOI interaction, so they’re not associated with the same serious risk.

Combining selegiline with drugs that affect serotonin or other monoamines can trigger life‑threatening interactions. Meperidine has serotonergic properties, and when used with MAO inhibitors like selegiline, it can precipitate serotonin syndrome and dangerous blood pressure changes. This risk makes it essential to avoid this pairing. Acetaminophen and ibuprofen don’t carry that same serotonergic interaction with MAOIs, and loratadine is an antihistamine with no strong MAOI interaction, so they’re not associated with the same serious risk.